We are at the Department of Biomedical Engineering in the University of Michigan, Ann Arbor. Our lab develops computer models for drug discovery and understanding cellular metabolism. Our recent research includes designing drug combinations for antibiotic resistant bacteria, developing a computer model of M. tuberculosis metabolism, and discovering a new mechanism of pathogen clearance by killer T-cells. We are also developing new methods to simulate the metabolism of microbes, cancer- and stem-cells.

See our full list of publications here

We are looking for students and postdocs interested in computational biology to join our lab. Please contact Sriram with your CV at csriram@umich.edu


Recent articles & press coverage




Systems biology

We are developing novel computational tools to simulate cellular metabolism and regulation. 

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We are developing computational tools to design new drug combinations to counter antibiotic resistant bacteria such as MRSA (pictured above). 

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